I really hated day 2! My routine breaker was to stand at the computer. I took the chair away so I wouldn't forget and use it. The morning was the worst part, because I usually stumble out of bed, grab my coffee, and blob out in the computer chair while catching up on emails and forums. Wasting time just isn't as much fun when you can't sit down.
I had to prop up the keyboard and mouse on boxes so I could reach them. I don't have a desk job, but I do generally spend 2-3 hours on the computer at various times throughout the day. I definitely cut down on my computer time because of this change.
Day 3 was a breeze. I'm left-handed, and I switched to my right hand for all of my eating and drinking. No problem; I was a lot more coordinated than I thought I would be, and it didn't require much mental effort.
Today is day 4: Putting on the toilet paper roll upside-down. Because I'm doing it intentionally, it's not bothering me nearly as much as when it happens on accident.